Growth hormone deficiency is a medical condition, caused by dysfunction of the pituitary gland in which the body does not produce enough growth hormone.
Growth hormone also called as somatotropin is a polypeptide hormone which stimulates growth cell production and cell reproduction.Both Adults And Children Are Affected ?
Children with the complete absence of growth hormone secretion usually present before reaching the age of 3 years.
In adults, the age of presentation usually occurs between the fourth and fifth decades of life and can be of any sex.
Growth hormone deficiency can be congenital or acquired in childhood or adult life. It can be partial or complete.
Mainly of two types:
The following may be the causes of GHD:
• Mutation of specific gene
• Congenital diseases such as Turner syndrome
• Congenital malformation involving the pituitary e.g posterior pituitary ectopia
• Chronic renal insufficiency
• Intracranial tumors
• Some infants who are small for gestational age
• Autoimmune inflammation
• Reduced male penis size.
• Exaggerated jaundice
• Delayed physical maturation
• Delayed puberty
Recognised effects include:
• Increased 5 alpha reductase
• Reduced sex hormone binding globulin
• Reduced muscle mass and strength
• Baldness in men
• Reduced bone mass and osteoporosis
• Reduced energy
• Impaired concentration and memory loss
• Increased body fat particularly around the waistline
• Increased levels of fibrinogen and plasminogen
• A physical examination including weight, height and body proportion will show signs of slowed growth rate. The child will not follow the normal curves.
• Hand X-ray can determine bone age.
• Stimulation test
• MRI of the Head
Pituitary tumors and some of the congenital anomalies that occur in children may require surgical resection.
When treated with GH, a severely deficient child will begin to grow faster within months. In the first year of treatment, the rate of growth may increase from half as fast as other children are growing to twice as fast.
GH treatment can confer a number of measurable benefits to severely GH-deficient adults, such as enhanced energy and strength, and improved bone density.
• Adrenal insufficiency
If left untreated, growth hormone deficiency will lead to short stature and delayed puberty.
• Dwarfishness. Immature development of parts of the body.
• Weak memory. Difficult comprehension.
• Childishness in old people.
• Agg. Cold
• Children with a thin body and big head and an enlarged abdomen.
• Slow development. Slow learning to walk and talk.
• Bad assimilation. Defective nutrition.
• Chilly. Agg: cold, uncovering.
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