Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria
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Werner syndrome is extremely rare syndrome, which was names after C.W. Otto Werner, a German physician who described the syndrome in 1904 in his thesis. Werner syndrome is a hereditary condition due to gene mutation of chromosome 8 encoding Werner’s protein. There are 25% chances that a child inherits two mutations and be affected by Werner’s syndrome.

The condition is characterized by the premature aging with increased risk of cancer and other disease. The syndrome develops as the sign of aging, loss of hair or graying of hair which appears in early teenage where as cataract, type2 diabetes and osteoporosis may develop in 30years of age. The most common causes of death by Werner’s syndrome are cancer, heart attack and stroke.

Races affected by Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

No racial predilection is reported.

Age/sex prevalance of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

Both sexes are equally affected. The onset of the disease is seen at the age of teens until 30 years of age.

Causes of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

• Genetic mutation of chromosome 8
• Hereditary/ inherited

Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria Signs and Symptoms

• Short stature
• Thin skin on the acreal surface
• Muscle atrophy is noted
• Skull large, with a disproportionate lower part of the face
• Wrinkling and aging of the face
• Sclerodermalike look of nose, nose is pinched
• Lips atrophy is a typical
• Cheeks are sunken because of fat loss, which causes the birdlike face appearance
• Loss of subcutaneous fat complicated with ulceration on shin and feet
• Graying of hair
• Loss of hair
• Nail dystrophy
• High- pitched, squeaky or hoarse voice
• Flat feet
• Type 2 diabetes mellitus
• Any type of cancer
 Osteoporosis
• Premature arteriosclerosis
• Cataracts
• Heart and artery disease
• Premature menopause in females

Investigations of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

• Complete case history
• Physical examination
• Blood sugar level
• Lipid profile test
• Eye examination
• Urinary and serum hyaluronic acid level test
• Sequence analysis for Werner’s syndrome
• Western blot

Treatment of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

• Genetic counseling
• Diabetes treatment
• Treatment for heart disease
• Vitamin C supplements
• Surgery

Complications of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

Increased breast cancer cases are seen in women of some races as chinese.

Prognosis of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

The life span on average is mid 40s, death occurs between this age.

Differential diagnosis of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

• Mixed connective tissue disease
• Hutchinson-gilford progeria syndrome
• Rothmund-thomsdon syndrome
• Systemic sclerosis

Diet / management of Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

• Regular physical activities should be there.
• Provide your child shoes with cushion or comfort inserts
• Keep immunization up to date.
• Eat balanced diet
• Add vitamin C supplements to diet

Homeopathic treatment for Werner Syndrome/ Adult Progeria/ Adult Premature Aging Syndrome/ Pangeria

Baryta Carbonica:
• Mental deficiency and emotional immaturity
• Slow physical growth.
• Needs reassurance as they feel they are slow than their friends
• Passive, shy with extreme difficulty to make decisions.
• Slow growth like dwarfism with chronic inflammation of swollen tonsils.
• Hard swelling of the cervical glands is common with difficulty swallowing liquids or saliva.
• Child breathes from mouth.

Calcarea Carbonica:
• Metabolic problems, difficulty assimilating nutrients.
• Slow teething, walking and talking
• Recurrent illness with swollen glands.
• Tendency to be overweight with big belly (but they can be quite skinny).
• Poor stamina
• Cold hands and feet, tends to sweat on back of the neck at night in bed.
• Skin eruptions and asthma.
• Constipated all the time.

Silica Marina:
• Child very delicate well behaved.
• Slow development, low appetite, and defective assimilation of nutrients.
• Bone disorders after vaccination.
• Tends to suffer from recurrent infections.
• Thin hair, skin eruptions, weak teeth, bones and slow growth.
• Worse from cold and have poor capacity to absorb minerals.
• Baby cannot tolerate milk, has projectile vomiting and weight loss.
• In infants blockage of tear duct.
• Constipation with bashful stool

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