The spleen is an organ which is located in the upper left quadrant of the abdomen and protected under the lower left ribs.
Splenomegaly is an enlargement of the spleen beyond its normal size.
Blood enters the spleen through the splenic artery and leaves through the splenic vein. If the pressure within the vein increases or if the splenic vein becomes blocked, blood cannot leave the spleen and it may swell.
Primary hypersplenism –problem within the spleen
Secondary hypersplenism –it results from another disease such as chronic malaria, blood disorder, and rheumatoid arthritis
Inflammatory splenomegaly– develops due to acute enlargement of the spleen in association with various infections or inflammatory processes and results from an increase in the defense activities of the organ.
Congestive splenomegaly-develops because of cirrhosis with portal hypertension or congestive heart failure
Infectious splenomegalyRaces affected by Splenomegaly
No racial differences
Female-to-male incidence ratio of 2:1. No age differences
Enlargement of spleen takes place when spleen works excessively in filtering or manufacturing the blood cells
• Viral infections
• Bacterial infection
• Parasitic infections
• Portal hypertension and portal vein obstruction
• Splenic vein pressure/blockage: Cancers – Hodgkins lymphoma and non-Hodgkins lymphoma
• Metabolic disorders
• Cirrhosis of the liver – which can increase the blood pressure inside the vessels of the spleen.
• Cystic fibrosis –characterized by excessive mucus production, particularly in the lungs and pancreas.
• Cytomegalovirus – a common viral infection that causes mild, flu-like symptoms.
• Hodgkin’s disease – cancer of the lymphatic system.
• Leukaemia – cancer of the bone marrow
• Lymphoma – cancer of the lymph nodes.
• Malaria –Parasitic infection
• Weakness, fatigue
• Pain on the upper left side of the abdomen
• Enlarged spleen felt by palpating abdomen
• Recurrent infections
• Enlarged spleen pushes towards stomach causing –loss of appetite, sense of fullness while eating and anorexia
• Pain radiating to left shoulder
• Shortness of breath
• Cool, clammy sweaty skin
• Physical examination
• Complete blood count
• CT/MRI of the abdomen
• Bone marrow biopsy
• Chemotherapy /radiation
The prognosis in case of splenomegaly is usually excellent. Depending upon the underlying cause, the enlarged spleen may return to normal size and function on treating the disease.
• Thrombocytopenia (decrease in platelet count)
• Leucopenia ( decrease in white blood cells )
• Viral hepatitis
• Iron deficiency anemia
• Infective endocarditis
• Infective mononucleosis
• Budd –Chairi syndrome
• A left sided remedy
• Anaemic patients with spleen affected
• Enlargement of spleen with pain radiating up the left side
Cinchna officinalis (China )
• Liver and spleen swollen.
• Debility with loss of vital fluids
• Severe flatulence colic
• Nervous system is sensitive, physical or mental effort aggravates.
• Cutting pain in abdomen
• Unquenchable thirst
• Sweats while eating
• Salt craving
• Sour taste and nausea in the morning
• Weight and pain in stomach
• Colic in lower region
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