Proteus Syndrome/Weidemann Syndrome

Weidemann Syndrome? Proteus Syndrome? What is this? What causes this problem? Is it curable? What are the signs and symptoms? How can homeopathy help you? All of this and more answered, in this post and of course our doctors always there to help you. Just fill in your details in the form down below and we will answer all your questions for FREE!

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What is Proteus syndrome?

Proteus syndrome is a rare condition that can lead to various clinical disorders especially overgrowth of skin, bone, tissue, vascular malformations, development of bone is not typical or normal overgrowth is seen. Multiple systems deformities are associated with this syndrome and lead to great difficulty in leading a normal routine life.

Is there any type of Proteus syndrome?

Classification of Proteus syndrome done on basis of presentation of symptoms

Type 1 presented as

• Connective tissue nevus is present in this type.

Type 2 present following features

• Nevus of epidermal tissue

• Unequal overgrowths of one limb or both the limbs: limbs, cranium, spinal vertebrae, spleen, thymus gland, even external auditory meatus

• Tumors of a female reproductive system, bilateral ovarian cystadenomas, parotid gland adenoma especially in patients of a young age group of Proteus syndrome that is below the age of 20 years.

Type 3 consist of following presentations

• Increase in size of adipose tissue or lipoma.

• Malformations of veins, capillaries or lymph vessels.

• A face of the patient shows the following features: long face, palpebrae ptosis is slanting down, the nasal bridge is depressed, nares are anteverted, and patient mouth is open at resting time.

What is the cause of Proteus syndrome?

Proteus syndrome is a genetic disorder. The most common cause is the mutation in genes AKT1 kinase. These genes are present on 26 number of chromosomes or 29 numbers of the chromosome.

Mutation of genes can occur due to stress in mother during pregnancy, any major trauma to mother’s health during pregnancy, exposure to nuclear radiations during pregnancy can also be a cause.

Signs and symptoms of Proteus syndrome?

The asymmetrical growth of bones of limbs, cranium, and digital bones.

• Due disproportionate overgrowth and focal atrophy give the patient a unique presentation in the form of an elongated thorax, gracile neck, muscular hypertrophy of the thighs wasting up of the upper arm.

• The recurrent occurrence of pneumonia.

• Reduction intolerance of exercise.

• Shortness of breath.

• Splenomegaly can occur in some patients.

• Lipomas on the skin, connective tissue nevi.

• Capillary hemangiomas are seen in a greater number of patients.


• Mental retardation in children with learning difficulties.

• Seizures are a very common feature of Proteus syndrome.

• The face of the patient shows these features: long face, palpebrae ptosis is slanting down, the nasal bridge is depressed, nares are anteverted, and patient mouth is open at resting time.

What is the life expectancy of a person with Proteus syndrome?

Life expectancy is 9 months to 29 years and it is according to the severity of the abnormalities. The major cause of premature death is pulmonary thromboembolism and respiratory failure, which are predisposed by vascular malformations, surgical convalescence, and (in extreme cases of deformity) by restricted mobility.

How do you treat Proteus syndrome?

There is no cure for proteus syndrome.

There is surgery to remove skin overgrowths and excess tissue. Doctors may also suggest surgically removing growth plates in the bone to prevent excessive growth.

Symptomatic treatment is possible with homeopathic medicines.

What are the complications?

• Macrocephaly, macroglossia, and cranial or auditory canal hyperostosis.

• Epidermal nevi, connective tissue nevi, lipomas or vascular malformations.

• Scoliosis with or without unusual habitus.

• Pulmonary cystic malformation.

• Pulmonary embolism, deep vein thrombosis.

• Strabismus.

• Dental abnormalities.

• Learning disabilities and mental retardation.

• Ovarian and parotid gland tumors.

• Splenomegaly or thymus gland enlargement.

For more information, you can visit NIH and Wikipedia.

Proteus Syndrome

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