Lichen Amyloidosis

Lichen amyloidosis is a cutaneous condition characterized by the appearance of occasionally itchy lichenoid papules, appearing  on the shins bilaterally.

lichen amyloidosis

 

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Age / Sex of Lichen Amyloidosis

The disease occurs most frequently in persons aged 50-60 years. It is more common in males than in females.

Race of Lichen Amyloidosis

It is believed to be more common in persons of Chinese ancestry

Causes

Amyloid  deposits in lichen amyloidosis bind to antikeratin antibodies.These deposits contain sulfhydryl groups, pointing to altered keratin as a source for these deposits.

Signs and Symptoms

Presents as intensely pruritic, red brown hyperkeratotic papules most commonly seen in pretibial surfaces i.e on shins.

Investigations

A skin biopsy may be performed in lichen amyloidosis.

Treatment

• Sedative antihistamines
• Topical and intralesional steroids
• Topical dimethyl sulfaoxide , a chemical solvent
• Surgical care :Include laser vaporization, dermabrasion and excision of individual lesion.Any of these can be the choice of treatment.

Differential diagnosis

• Prurigo nodularis
• Lichen sclerosus et Atrophicus

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