Glucagonoma is a very rare pancreas tumor of the islet cells of pancreas, which release insulin and glucagon. Physiologically, glucagon is an important factor in controlling homeostasis of glucose and certain amino acids. It is also used to treat heart failure.

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Age/sex prevalence of Glucagonoma

It mostly affects people age from 19-84 years, with a mean age of 55 years. Females are more likely to have Glucagonoma as compared to men.

Causes of Glucagonoma

The cause of glucagonoma pathology remains unknown, although some factors play an important a role are:

•Genetic factors

•Family history of Endocrine Neoplasia type 1 syndrome (MEN I)

Signs and Symptoms of Glucagonoma

•Glucose intolerance

•High blood sugar

•Increased appetite


•Excessive thirst

•Frequent urination

•Inflamed mouth and tongue

•Nocturnal urination

•Skin rash

•Rash on face, abdomen, buttock, feet

•Skin crusty or scaly

•Skin lesions filled with clear fluid and pus

•Weight loss

Investigation for Glucagonoma

•Complete case history

•Physical examination

•CT scan

•Glucagon level in the blood

•Glucose level in blood

Treatment for Glucagonoma



Prognosis of Glucagonoma

In cases where tumor is only in pancreas, surgical removal of tumor is successful and survival rate of 85% is recorded. Whereas its cancer has spread to liver even after surgery survival rate is approximately 20%.

Complications of Glucagonoma

•Liver cancer

•High blood sugar level

•Metabolic problems

•Tissue damage

Differential diagnosis of Glucagonoma

•Acrodermatitis enteropathica



•Type 1, Diabetes Mellitus

•Type 2, Diabetes Mellitus

•Paraneoplastic Syndromes



Management of Glucagonoma

•Yoga and meditation help

•Take balanced diet

•Quit smoking and alcohol

•Drink plenty of water during day avoid excessive water intake during night

•Keep a close look on weight and consult doctor in case one observe drop in it.

Homeopathic remedies for Glucagonoma

Cadmium sulphuratum

•Cancer of stomach and pancreas

•Vomiting of black, coffee-ground matter

•Bleeding in the stomach

•Cutting, twisting sensation

•Burning pains with intense chilliness and weakness

Ceanothus americanus 

•Cancer of spleen, pancreas and liver

•Pain worse lying on left side

•Little movement cause pain


•Stomach, pancreas and upper intestinal tract are most effected

•Yellow thick, ropy secretions

•Distended abdomen, profuse perspiration

•Extreme weakness and intense pain

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