Euthyroid hyperthyroxinemia is defined as a condition in which the total serum or free thyroxine T4 concentration is abnormal without evidence of clinical thyroid disease.Age / Sex of Euthyroid Hyperthyroxinemia
Older men who are weak or delicate may manifest higher free thyroxine levels.
Physiological causes: Pregnancy, Delayed puberty, Estrogen intake
Drugs: Heroin, methadone, perphenazine, Heparin, propranolol etc.
Thyroid hormone resistance syndrome
Hyperthyroxinemia of systemic illness like liver disease, acute psychosis, islet cell carcinoma, HIV
Thyroid hormone resistance signs include following:
• Increased metabolic rate
• Liver disease signs include the following:
• Obtain a detailed clinical evaluation
• Measurement of TSH by a third generation assay
• Measurement of free T4
The tumors, such as glucagonoma, islet cell tumors, or estrogen-secreting tumors, may be resectable.
• Most of the conditions are self-limiting.
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