Calciphylaxis is a syndrome in which calcium deposits in the vascular system forming thrombus and causing skin necrosis. This disease is found in kidney patients who are stage 5 of chronic kidney failure.
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Who Are More Affected By Calciphylaxis?
Females are commonly affected by the disease. Ratio of female to male is 3:1.Races affected
Individuals of any age can be affected by this disease. Most common age group to be affected is 48 years of age.
Although this disease can occur in individuals of any race whites are more affected.
How Calciphylaxis Is Caused By Different Conditions?
There are many disorders which are related to calciphylaxis and are mentioned belowSign and symptoms of this fatal disease
•Conditions which are associated include chronic renal failure, elevated calcium-phosphate product, hyperparathyroidism, vascular calcification, hypercalcemia, hyperphosphatemia.
•Other associated conditions include coagulation abnormalities, iron dextran infusion, and aluminum toxicity.
•If there are systemic inflammations then they are considered to be the predisposing factor.
•Ischemic lesions of subcutaneous fatIs There Any Test To Diagnose Calciphylaxis?
•Ischemic skin muscle lesions
•Necrosis of skin
•Calcification of skin blood lesions
There is no such diagnostic test for this disease.How Calciphylaxis Can Be Managed?
The disease is diagnosed by the physical symptoms such as ischemic skin lesions.
There is no specific treatment for this fatal disease. Treatment could include the followings pointsPrognosis
•Local tissue trauma should be avoided
•Adequate pain control
Prognosis of the disease is not very good. Mortality rates are high.
How Calciphylaxis Can Leads To Complications?
•Lesions of calciphylaxis can lead to ulcers which take a long time to heal or even nonhealing and can even lead to cutaneous gangrene.Differential diagnosis
•In patients where the involvement of calciphylaxis occurs in internal parts, it can lead to gastrointestinal hemorrhage, infarction or even organ failure.
•Sometimes patient treated with calcimimetics, sodium thiosulfate may even lead to hypocalcemia.
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•Brown recluse spider bite