Calcyphylaxis

Calciphylaxis is a syndrome in which calcium deposits in the vascular system forming thrombus and causing skin necrosis. This disease is found in kidney patients who are stage 5 of chronic kidney failure.

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calciphylaxis

Who Are More Affected By Calciphylaxis?
Females are commonly affected by the disease. Ratio of female to male is 3:1.
Individuals of any age can be affected by this disease. Most common age group to be affected is 48 years of age.
Races affected
Although this disease can occur in individuals of any race whites are more affected.
How Calciphylaxis Is Caused By Different Conditions?
There are many disorders which are related to calciphylaxis and are mentioned below
•Conditions which are associated include chronic renal failure, elevated calcium-phosphate product, hyperparathyroidism, vascular calcification, hypercalcemia, hyperphosphatemia.
•Other associated conditions include coagulation abnormalities, iron dextran infusion, and aluminum toxicity.
•If there are systemic inflammations then they are considered to be the predisposing factor.
Sign and symptoms of this fatal disease
•Ischemic lesions of subcutaneous fat
•Ischemic skin muscle lesions
•Secondary hyperparathyroidism
•Necrosis of skin
•Calcification of skin blood lesions
Is There Any Test To Diagnose Calciphylaxis?
There is no such diagnostic test for this disease.
The disease is diagnosed by the physical symptoms such as ischemic skin lesions.
How Calciphylaxis Can Be Managed?
There is no specific treatment for this fatal disease. Treatment could include the followings points
•Dialysis
•Clot-dissolving agents
•Hyperbaric oxygen
•Local tissue trauma should be avoided
•Urgent parathyroidectomy
•Adequate pain control
Prognosis
Prognosis of the disease is not very good. Mortality rates are high.
How Calciphylaxis Can Leads To Complications?
•Lesions of calciphylaxis can lead to ulcers which take a long time to heal or even nonhealing and can even lead to cutaneous gangrene.
•In patients where the involvement of calciphylaxis occurs in internal parts, it can lead to gastrointestinal hemorrhage, infarction or even organ failure.
•Sometimes patient treated with calcimimetics, sodium thiosulfate may even lead to hypocalcemia.
Differential diagnosis
•Venous ulcers
•Wegener granulomatosis
•Erythema nodosum
•Necrotizing fasciitis
•Vibrio vulnific UA infection
•Pyoderma gangrenosum
•Lupus erythematosus, bullous
•Bullous pemphigoid
•Cellulitis
•Brown recluse spider bite

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