Vitamin B6/ Pyridoxine

Vitamin B6 is a water soluble vitamin i.e. it get dissolved in water. The body cannot store them. Leftover amount of vitamin B6 leaves the body through urine. Vitamin B6 is the master vitamin for processing amino-acids, which are the building blocks of all proteins and some hormones. It also needed in making of hormones like serotonin, melatonin and dopamine. So a well balanced diet with proper nutrients and well balanced vitamin supplements is recommended.

Referral range of Vitamin B6

Pediatric referral range:
• Infants 0-6months: 0.1 mg/day(adequate intake)
• Infants 7months-1 year: 0.3mg/day(adequate intake)
• Children 1-3 years: 0.5 mg/day (RDA)
• Children 4-8 years: 0.6mg/day (RDA)
• Children 9-13 years: 1 mg/day (RDA)
• Boys 14-18 years: 1.3 mg/day (RDA)
• Girls 14-18 years: 1.2 mg/day (RDA)

Adult referral range:
• 19-50 years: 1.3 mg/day (RDA)
• Men 51 years and older: 1.7 mg/day (RDA)
• Women 51 years and older: 1.5 mg/day (RDA)
• Pregnant women: 1.9 mg/day (RDA)
• Breast feeding women: 2.0 mg/day (RDA)
*RDA: Recommendations for dietary allowance .

Interpretation of Vitamin B6
Higher amount of Vitamin B6 indicates
• Difficulty coordinating movements
• Numbness
• Sensory changes
• Extreme sensitivity to sunlight
• Nausea
• Heartburn

Lower amount of vitamin B6 indicates:
• Confusion
• Convulsions
• Depression
• Insomnia
• Anemia
• Irritability
• Muscle twitching
• Dermatitis
• Mouth and tongue sores

Collection for Vitamin B6
Specimen type: Blood plasma
Container: Vacationer, green top
Collection method: Venipuncture
Specimen volume: 1mL
• Overnight fasting specimen
• No vitamin supplements in preceding 24 hours
• Transport in light-protective container
• Centrifuge at 4o C; refrigerate immediately

Indication of Vitamin B6
Serum analysis is indicated for the following:
• Evaluation of suspected vitamin B6 deficiency
• Diagnosis of hypophosphatasia

Other manifestations of vitamin B6 deficiency may include the following:
• Scaling of the skin
• Severe gingivitis
• Cheilosis
• Stomatitis
• Irritability
• Weakness
• Dizziness
• Diarrhea