Myeloproliferative Glomerulonephritis

GlomerulonephritisGlomerulonephritis is a term used when the glomeruli become inflamed which allows the blood cells and proteins to pass through the walls of glomerulus in urine. Membranoproliferative glomerulonephritis (MPGN) also called mesangiocapillary glomerulonephritis is one of rare forms of glomerulonephritis.Age/Sex

Type1 MPGN primarily affects women more often than men.
Type 2 MPGN occurs more commonly in children and young adults.

Race Affected

It predominantly affects the white population. Causes of Myeloproliferative Glomerulonephritis

•Idiopathic
•Autoimmune diseases: SLE, Sjögren syndrome, Rheumatoid arthritis, scleroderma, celiac disease.
•Chronic infection: Viral, Bacterial, Protozoal
•Malignant neoplasms
•Paraprotein deposition disease
•Chronic thrombotic microangiopathies

Symptoms of Myeloproliferative Glomerulonephritis

•Hematuria: Urine may be tea colored
•Swelling or puffiness (oedema) around eyes, tummy, feet and legs
•Hypertension
•Fatigue

Differential Diagnosis of Myeloproliferative Glomerulonephritis

•Acute glomerulonephritis
•IgA nephropathy
•Lupus nephritis
•Post streptococcal Glomerulonephritis
•Rapidly progressive Glomerulonephritis

Investigations of Myeloproliferative Glomerulonephritis

•CBC
•Laboratory test:
May show normocytic normochromic anemia.
Hyperlypedemia and low albumin.
•Urine test: shows
Hematuria
Protenuria
•Kidney test:
Elevated serum creatinine and BUN levels
Decreased Glomerulo filteration rate(GFR)
•Kidney biopsy

Treatment of Myeloproliferative Glomerulonephritis

Immunosuppressives
Corticosteroids
Antiplatelet therapy

Diet and Management

Dietary considerations include sodium, protein, and lipid intake

Prognosis of Myeloproliferative Glomerulonephritis

Prognosis is poor.

Homoeopathic Treatment of Myeloproliferative Glomerulonephritis

Apocynum:
This remedy acts upon URINARY ORGANS producing diuresis and removing the
dropsical effusions.
Dropsies are usually accompanied by digestive disturbances- nausea
vomiting and great thirst; drowsiness and difficult breathing may
accompany these symptoms.
Dropsy; after Haemorrhage; quinine.
Bloated < lying down passes off after sitting up.

Arsenic album: Urine; scanty burning involuntary. Retention of urine; as if the bladder were paralyzed after parturition. Urine black as if mixed with dung.

Cantharis: Nephritis; acute parenchymatous. Serous effusions. Urine is burning scalding; with cutting intolerable urging and fearful tenesmus or dribbling. Bloody urine Acute nephritis, cystitis, nephritic colic Renal colic > somewhat by pressure on glans penis.
Kobaltum:
Albuminuria.
Smarting at the meatus at the end of urination.
Urine has a strong pungent smell.