Calciphylaxis is a syndrome in which calcium deposits in the vascular system forming thrombus and causing skin necrosis. Calciphylaxis disease is found in kidney patients who are stage 5 of chronic kidney failure.
Age/Sex prevalence of calciphylaxis
Females are commonly affected by calciphylaxis ration of female to male is 3:1.
Races affected by calciphylaxis
Individuals of any age can be affected by calciphylaxis. Most common age group to be affected is 48 years of age.
Although calciphylaxis can occur in individuals of any race whites are more affected.
Causes of calciphylaxis
There are many disorders which are related to calciphylaxis and are mentioned belowSign and symptoms of calciphylaxis
•Conditions which are associated include chronic renal failure, elevated calcium-phosphate product, hyperparathyroidism, vascular calcification, hypercalcemia, hyperphosphatemia.
•Other associated conditions include coagulation abnormalities, iron dextran infusion, and aluminum toxicity.
•If there are systemic inflammations then they are considered to be the predisposing factor.
•Ischemic lesions of subcutaneous fatInvestigations of calciphylaxis
•Ischemic skin muscle lesions
•Necrosis of skin
•Calcification of skin blood lesions
There is no such diagnostic test for calciphylaxis.Treatment of calciphylaxis
The disease is diagnosed by the physical symptoms such as ischemic skin lesions.
There is no specific treatment for calciphylaxis. Treatment could include the followings pointsPrognosis of calciphylaxis
•Local tissue trauma should be avoided
•Adequate pain control
Prognosis of calciphylaxis is not very good. Mortality rates are high.
Complications of calciphylaxis
•Lesions of calciphylaxis can lead to ulcers which take a long time to heal or even nonhealing and can even lead to cutaneous gangrene.Differential diagnosis of calciphylaxis
•In patients where the involvement of calciphylaxis occurs in internal parts, it can lead to gastrointestinal hemorrhage, infarction or even organ failure.
•Sometimes patient treated with calcimimetics, sodium thiosulfate may even lead to hypocalcemia.
•Vibrio vulnific UA infection
•Lupus erythematosus, bullous
•Brown recluse spider bite